Which of the following is a legitimate reason for a pharmacist to refuse to fill a prescription?

Refusing to fill a prescription due to suspicion of drug misuse is a legitimate reason for a pharmacist to exercise their professional judgment. Pharmacists play a crucial role in ensuring the safe and appropriate use of medications, which includes assessing whether a prescription is being issued in a manner consistent with its intended therapeutic use. If a pharmacist has concerns that the prescribed medication may be misused—such as indications of potential abuse, diversion, or other forms of non-compliance—they are ethically and legally obligated to refuse to fill that prescription to protect the patient's health and safety.

In contrast, lack of prescription insurance, patient preference for a specific brand, and requests for a higher dosage do not inherently warrant refusal. While a pharmacist may discuss the implications of these situations or suggest alternatives, they generally do not constitute valid grounds for denying a prescription. Understanding the nuances of these scenarios is essential for pharmacists to navigate their responsibilities and ensure patient care is prioritized while adhering to legal and ethical standards.